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Sexual activity carries a potential cardiac risk for patients with preexisting cardiovascular disease. Therefore, treatments for erectile dysfunction, including Tadalafil, should not be used in men with cardiac disease for whom sexual activity is inadvisable. The potential cardiac risk of sexual activity in patients with preexisting cardiovascular disease should be considered by physicians. The following groups of patients with cardiovascular disease were not included in clinical trials: • Patients with myocardial infarction within the last 90 days • Patients with unstable angina or angina occurring during sexual intercourse • Patients with heart failure in the last 6 months • Patients with uncontrolled arrhythmias, hypotension (<90/50 mm Hg) or uncontrolled hypertension; and • Patients with a stroke within the last 6 months

Priapism has been reported with PDE5 inhibitors, including Tadalafil. Patients who experience erections lasting > 24 hours should be instructed to seek immediate medical assistance. Penile tissue damage and permanent loss of potency may result if priapism is not treated immediately.

Cialis should be used with caution in patients who have conditions that might predispose them to priapism (multiple myeloma or leukemia, sickle cell anemia), or in patients with anatomical deformation of the penis.

Determining the potential underlying causes and the identification of appropriate treatment following an appropriate medical assessment must be included in the evaluation of erectile dysfunction.

The safety and efficacy of combinations of Tadalafil and other treatments for erectile dysfunction have not been studies. Combining both drugs is not recommended.

No data are available in patients with severe hepatic impairment, therefore, caution should be exercised when prescribing Cialis to this patient group.

Caution should also be exercised when prescribing Cialis to patients who are taking alpha-blockers for example, doxazosin, as simultaneous administration may lead to symptomatic hypotension in some patients.